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Consumption of krill oil and supplemented diet significantly reduced the arthritis scores and hind paw swelling when compared to a control diet not supplemented with EPA and DHA. However, the arthritis score during the late phase of the study was only significantly reduced after krill oil administration. Furthermore, mice fed the krill oil diet demonstrated lower infiltration of inflammatory cells into the joint and synovial layer hyperplasia, when compared to control. Inclusion of fish oil and krill oil in the diets led to a significant reduction in hyperplasia and total histology score. Krill oil did not modulate the levels of serum cytokines whereas consumption of fish oil increased the levels of IL-1alpha and IL-13.


In this study, a blood level of 44 mL or higher resulted in 27 percent fewer cases of atherosclerotic heart disease, 32 percent decrease in heart failure, a whopping 59 percent reduction in heart attack and a 51 percent reduction in kidney failure. In addition, anemia decreased by 30 percent and skeletal disease (bone loss) was reduced by an astonishing 71 percent. Death rates and depression also were reduced in those with higher vitamin D levels. Currently there is no single medication whose benefits even come close to those of vitamin D.


According to the National Institutes of Health, more than 1 in 4 Americans 18 and older (26.2%) suffer from a diagnosable mental disorder each year.  Included in these mental disorders is depression, with Major Depressive Disorder recognized as the leading cause of disability in the U.S. for ages 15-44.  It affects nearly 15 million Americans, can develop at any age, and affects women more than men (1). Depression is estimated to cost our healthcare system more than $65 billion each year (2).

A new study (3 has found that low vitamin D levels may also influence mental health.  In the study, researchers analyzed data on 7, 970 non-institutionalized U.S. citizens aged 15 to 39 who participated in the NHANES II study (4).  In addition to providing blood samples during the study, patients also completed the Diagnostic Interview Study (5) to assess for Depression.


Current research has implicated vitamin D deficiency as a major factor in the pathology of at least 17 varieties of cancer as well as heart disease, stroke, hypertension, autoimmune diseases, diabetes, depression, chronic pain, osteoarthritis, osteoporosis, muscle weakness, muscle wasting, birth defects, periodontal disease, and more.



Urinary tract infection (UTI) by uropathogenic Escherichia coli (UPEC) is one of the most common infections, particularly affecting women. The interaction of FimH, a lectin located at the tip of bacterial pili, with high mannose structures is critical for the ability of UPEC to colonize and invade the bladder epithelium. We describe the synthesis and the in vitro/in vivo evaluation of α-d-mannosides with the ability to block the bacteria/host cell interaction. According to the pharmacokinetic properties, a prodrug approach for their evaluation in the UTI mouse model was explored. As a result, an orally available, low molecular weight FimH antagonist was identified with the potential to reduce the colony forming units (CFU) in the urine by 2 orders of magnitude and in the bladder by 4 orders of magnitude. With FimH antagonist 16b, the great potential for the effective treatment of urinary tract infections with a new class of orally available antiinfectives could be demonstrated.


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