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KRILL OIL
Consumption of krill oil and
supplemented diet significantly reduced the arthritis scores and hind paw
swelling when compared to a control diet not supplemented with EPA and DHA. However, the arthritis score during the late phase of the
study was only significantly reduced after krill oil administration.
Furthermore, mice fed the krill oil diet demonstrated lower infiltration of
inflammatory cells into the joint and synovial layer hyperplasia, when compared
to control. Inclusion of fish oil and krill oil in the diets led to a
significant reduction in hyperplasia and total histology score. Krill oil did
not modulate the levels of serum cytokines whereas consumption of fish oil
increased the levels of IL-1alpha and IL-13.
PUB MED
VITAMIN D3
In this study, a blood level of 44
mL or higher resulted in 27 percent fewer cases of atherosclerotic heart
disease, 32 percent decrease in heart failure, a whopping 59 percent reduction
in heart attack and a 51 percent reduction in kidney failure. In addition,
anemia decreased by 30 percent and skeletal disease (bone loss) was reduced by
an astonishing 71 percent. Death rates and depression also were reduced in
those with higher vitamin D levels. Currently there is no single
medication whose benefits even come close to those of vitamin D.
NATURAL HEALTH RESEARCH
INSTITUTE
VITAMIN D3
According to the National Institutes
of Health, more than 1 in 4 Americans 18 and older (26.2%) suffer from a
diagnosable mental disorder each year. Included in these mental disorders
is depression, with Major Depressive Disorder recognized as the leading cause
of disability in the U.S. for ages 15-44. It affects nearly 15 million Americans,
can develop at any age, and affects women more than men (1). Depression is
estimated to cost our healthcare system more than $65 billion each year (2).
A new study (3 has found that low
vitamin D levels may also influence mental health. In the study,
researchers analyzed data on 7, 970 non-institutionalized U.S. citizens aged 15
to 39 who participated in the NHANES II study (4). In addition to
providing blood samples during the study, patients also completed the
Diagnostic Interview Study (5) to assess for Depression.
NATURAL HEALTH RESEARCH INSTITUTE
VITAMIN D3
Current research has implicated vitamin D deficiency as
a major factor in the pathology of at least 17 varieties of cancer as
well as heart disease, stroke, hypertension, autoimmune diseases, diabetes,
depression, chronic pain, osteoarthritis, osteoporosis, muscle weakness, muscle
wasting, birth defects, periodontal disease, and more.
VITAMIN D COUNCIL D-MANNOSE
Urinary tract infection (UTI) by
uropathogenic Escherichia coli (UPEC) is one of the most common infections,
particularly affecting women. The interaction of FimH, a lectin located at the
tip of bacterial pili, with high mannose structures is critical for the ability
of UPEC to colonize and invade the bladder epithelium. We describe the
synthesis and the in vitro/in vivo evaluation of α-d-mannosides with the
ability to block the bacteria/host cell interaction. According to the
pharmacokinetic properties, a prodrug approach for their evaluation in the UTI
mouse model was explored. As a result, an orally available, low molecular
weight FimH antagonist was identified with the potential to reduce the colony
forming units (CFU) in the urine by 2 orders of magnitude and in the bladder by
4 orders of magnitude. With FimH antagonist 16b, the great potential for the effective treatment of urinary
tract infections with a new class of orally available antiinfectives could be
demonstrated.
PUB MED
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